Syntheses of Arylsulfone-thiazole Derivatives. IX
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Syntheses of protoporphyrin-IX derivatives bearing extended propionate side-chains.
In order to investigate the relationship between depth within membranes of singlet oxygen generation and effectiveness of photodynamic therapy of tumors, analogs of protoporphyrin-IX 1 bearing five 4 and seven 5 carbon atoms (in place of the 3-carbon atom chain in 1) were synthesized from monopyrrole precursors.
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The structure of anisomycin has been determined by X-ray investigation4 and the absolute configuration was confirmed by chemical correlation.5 Anisomycin has attracted considerable synthetic interest, and several synthetic studies, derivative syntheses as well as total syntheses, have been reported.6 Especially, the synthesis of its analogues has revealed the structure-activity relationship of ...
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ةصلاخلا بكرملل ةدیدج تاقتشم ریضحت ىلا ثحبلا يمری 4,3,1 ةیتلاا تلاعافتلا ءارجا للاخ نم لوزایادایاث : ًلاوأ : ب كرملل فیش ةدعاق ریضحت ) 2 و نیما 5 و تبكرم 4,3,1 لوزا یادایاث ( يلیفو یلكوینلا ضیو عتلا ءارجاو ةدعاقلل يرتسلاا ب كرملا نیو كت ى لا يدؤ یل مویدو صلا دیسكوثیا دو جوب ل ثیلاا تاتیسا ومورب عم ) 3 ( ، يذ لا یازاردیھلا عم ھتلعافم تمت ن 99 % د یازاردیھلا قتشم ریضحتل ) 4 ( فیش دعاوق نم د یدع...
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In an attempt to find a new class of antimicrobial agents, a series of thiazole derivatives containing furan moiety 3, 7, 8a,b, 10a-c and 12 were prepared via the reaction of 2-cyano-N-(furan-2-ylmethyl)acetamide (1) with phenyl isothiocyanate and α-halocarbonyl compounds. Also, many bithiazolidinone and pyranothiazole derivatives were synthesized through interaction of thiazolidinone 7 with ap...
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Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1950
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.70.1_16